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Acute IL-1RA treatment suppresses the peripheral and central inflammatory response to spinal cord injury

Abstract:

Background The acute phase response (APR) to CNS insults contributes to the overall magnitude and nature of the systemic inflammatory response. Aspects of this response are thought to drive secondary inflammatory pathology at the lesion site, and suppression of the APR can therefore afford some neuroprotection. In this study, we examined the APR in a mouse model of traumatic spinal cord injury (SCI), along with its relationship to neutrophil recruitment during the immediate aftermath of the i...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12974-020-02050-6

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
ORCID:
0000-0002-5623-5568
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International Spinal Research Trust More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Journal of Neuroinflammation Journal website
Volume:
18
Article number:
15
Place of publication:
England
Publication date:
2021-01-06
Acceptance date:
2020-12-09
DOI:
EISSN:
1742-2094
Pmid:
33407641
Language:
English
Keywords:
Pubs id:
1156446
Local pid:
pubs:1156446
Deposit date:
2021-09-21

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