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Molecular recognition of the native HIV-1 MPER revealed by STED microscopy of single virions

Abstract:

Antibodies against the Membrane-Proximal External Region (MPER) of the Env gp41 subunit neutralize HIV-1 with exceptional breadth and potency. Due to the lack of knowledge on the MPER native structure and accessibility, different and exclusive models have been proposed for the molecular mechanism of MPER recognition by broadly neutralizing antibodies. Here, accessibility of antibodies to the native Env MPER on single virions has been addressed through STED microscopy. STED imaging of fluoresc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-018-07962-9

Authors


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Role:
Author
ORCID:
0000-0001-6592-7630
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Role:
Author
ORCID:
0000-0002-4457-8096
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
10
Article number:
78
Publication date:
2019-01-08
Acceptance date:
2018-12-07
DOI:
EISSN:
2041-1723
Pmid:
30622256
Source identifiers:
959166
Language:
English
Keywords:
Pubs id:
pubs:959166
UUID:
uuid:4199a3f6-b786-496d-a114-de6152840276
Local pid:
pubs:959166
Deposit date:
2019-07-08

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