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Genome-wide association study for radiographic vertebral fractures: a potential role for the 16q24 BMD locus.

Abstract:

Vertebral fracture risk is a heritable complex trait. The aim of this study was to identify genetic susceptibility factors for osteoporotic vertebral fractures applying a genome-wide association study (GWAS) approach. The GWAS discovery was based on the Rotterdam Study, a population-based study of elderly Dutch individuals aged > 55 years; and comprising 329 cases and 2666 controls with radiographic scoring (McCloskey–Kanis) and genetic data. Replication of one top-associated SNP was pursu...

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Publication status:
Published

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Publisher copy:
10.1016/j.bone.2013.10.015

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Publisher:
Elsevier
Journal:
Bone
Volume:
59
Pages:
20-27
Publication date:
2014-02-01
DOI:
EISSN:
1873-2763
ISSN:
8756-3282
Source identifiers:
440470
Language:
English
Keywords:
Pubs id:
pubs:440470
UUID:
uuid:419b3aa0-e5c9-44cf-b55c-09ca14db0632
Local pid:
pubs:440470
Deposit date:
2014-07-04

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