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The increase in thymopoiesis following T cell progenitor therapy is dependent upon the input population and continued interaction between developing T cells and the thymic microenvironment

Abstract:

The inclusion of in vitro derived T cell progenitor (proT) therapy with hematopoietic stem cell transplant (HSCT) aids in the recovery of the thymus damaged by total body irradiation and improves de novo thymopoiesis. To understand the interaction between proTs and the thymic microenvironment, wildtype (WT) mice were lethally irradiated and given T cell deficient donor (Rag1-/-) marrow along with in vitro generated proT from WT donors, limiting mature T cell development to infused proT. Dono...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher:
American Association of Immunologists Publisher's website
Journal:
Journal of Immunology Journal website
Volume:
196
Issue:
1 Supplement 140.34
Host title:
Journal of Immunology
Publication date:
2016-05-17
Acceptance date:
2016-01-13
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
715267
Keywords:
Pubs id:
pubs:715267
UUID:
uuid:419bd563-3006-4473-a4af-c86163a26660
Local pid:
pubs:715267
Deposit date:
2017-10-17

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