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Thesis

An investigation of human regulatory T cell metabolic pathways

Abstract:

Regulatory T cells (Tregs) are essential to homeostatic immune tolerance. Clinical trials of autologous Treg cell therapy have demonstrated promising preliminary results, but there remain challenges to overcome including the problem of recipient-dependent expansion variability. Enhancing the suppressive function of expanded Tregs to reduce the required Treg dose would present a potential solution to this problem.

Cellular metabolism regulates immune cells through two interacting as...

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Division:
MSD
Department:
Surgical Sciences
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Role:
Supervisor
ORCID:
0000-0002-8279-7732
Role:
Examiner
Role:
Examiner
ORCID:
0000-0001-5733-3285
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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