Thesis
An investigation of human regulatory T cell metabolic pathways
- Abstract:
-
Regulatory T cells (Tregs) are essential to homeostatic immune tolerance. Clinical trials of autologous Treg cell therapy have demonstrated promising preliminary results, but there remain challenges to overcome including the problem of recipient-dependent expansion variability. Enhancing the suppressive function of expanded Tregs to reduce the required Treg dose would present a potential solution to this problem.
Cellular metabolism regulates immune cells through two interacting as...
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Authors
Contributors
+ Hester, J
Institution:
University of Oxford
Division:
MSD
Role:
Supervisor
+ Issa, F
Institution:
University of Oxford
Division:
MSD
Role:
Supervisor
ORCID:
0000-0002-8279-7732
+ Marelli-Berg, F
Role:
Examiner
+ Correia Botelho Chaves Ferreira, R
Role:
Examiner
ORCID:
0000-0001-5733-3285
Funding
+ Honjo International Scholarship Foundation
More from this funder
Funding agency for:
Hashimoto, H
Funder identifier:
http://dx.doi.org/10.13039/501100005951
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- Deposit date:
- 2022-06-20
Related Items
Terms of use
- Copyright holder:
- Hashimoto, H
- Copyright date:
- 2022
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