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Complete-proteome mapping of human influenza A adaptive mutations: implications for human transmissibility of zoonotic strains.

Abstract:

BACKGROUND: There is widespread concern that H5N1 avian influenza A viruses will emerge as a pandemic threat, if they become capable of human-to-human (H2H) transmission. Avian strains lack this capability, which suggests that it requires important adaptive mutations. We performed a large-scale comparative analysis of proteins from avian and human strains, to produce a catalogue of mutations associated with H2H transmissibility, and to detect their presence in avian isolates. METHODOLOGY/PRI...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0009025

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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National Institute of Allergy and Infectious Diseases More from this funder
National Institutes of Health More from this funder
Department of Health and Human Services More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
5
Issue:
2
Article number:
e9025
Publication date:
2010-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
48478

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