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Cutting edge: hierarchy of chemokine receptor and TCR signals regulating T cell migration and proliferation.

Abstract:

Chemokines play an important role in establishing the distribution of lymphocyte subpopulations in primary and secondary lymphoid tissues and in the recruitment of leukocytes to sites of inflammation. However, the potential of chemokines to down-regulate immune responses has not been demonstrated. We now show that certain chemokine gradients have the potential to suppress T cell activation by preventing formation of the immunological synapse, the specialized cell-cell junction that forms befo...

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Publisher copy:
10.4049/jimmunol.165.1.15

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Journal of Immunology
Volume:
165
Issue:
1
Pages:
15-19
Publication date:
2000-07-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
482668

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