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Elusive copy number variation in the mouse genome.

Abstract:

BACKGROUND: Array comparative genomic hybridization (aCGH) to detect copy number variants (CNVs) in mammalian genomes has led to a growing awareness of the potential importance of this category of sequence variation as a cause of phenotypic variation. Yet there are large discrepancies between studies, so that the extent of the genome affected by CNVs is unknown. We combined molecular and aCGH analyses of CNVs in inbred mouse strains to investigate this question. PRINCIPAL FINDINGS: Using a 2....

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0012839

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Wellcome Trust More from this funder
Engineering and Physical Sciences Research Council More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
5
Issue:
9
Article number:
e12839
Publication date:
2010-09-21
Acceptance date:
2010-08-16
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
79982
Language:
English
Keywords:
UUID:
uuid:41bfa593-bff0-4d64-828a-04a0a1846af0
Local pid:
pubs:79982
Deposit date:
2012-12-19

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