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Thesis

Functional and inhibition studies on 2-oxoglutarate-dependent oxygenases

Abstract:

This thesis explores roles of 2-oxoglutarate-dependent (2OG) oxygenases as interfaces that modulate steps in the flow of genetic information in cells in response to oxygen availability. Chapter 1 introduces mechanistic, biochemical and physiological aspects of major subfamilies of 2OG oxygenases, and their established regulatory roles in cells. In addition, structural and functional aspects of the ribosome and the translation process are discussed, with a focus on post-translational riboso...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Research group:
Prof. Christopher J. Schofield
Oxford college:
Hertford College
Role:
Author

Contributors

Division:
MPLS
Department:
Chemistry
Role:
Supervisor
Division:
MPLS
Department:
Chemistry
Role:
Supervisor
More from this funder
Funding agency for:
Thalhammer, A
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK

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