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High resolution HLA haplotyping by imputation for a British population bioresource.

Abstract:

This study aimed to establish the occurrence and frequency of HLA alleles and haplotypes for a healthy British Caucasian population bioresource from Oxfordshire. We present the results of imputation from HLA SNP genotyping data using SNP2HLA for 5553 individuals from Oxford Biobank, defining one- and two-field alleles together with amino acid polymorphisms. We show that this achieves a high level of accuracy with validation using sequence-specific primer amplification PCR. We define six- and ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.humimm.2017.01.006

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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National Institute for Health Research More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Human Immunology Journal website
Volume:
78
Issue:
3
Pages:
242–251
Publication date:
2017-01-19
Acceptance date:
2017-01-17
DOI:
EISSN:
1879-1166
ISSN:
0198-8859
Language:
English
Keywords:
Pubs id:
pubs:673339
UUID:
uuid:420b9152-33a0-4e3e-8f2d-46120d4daf1f
Local pid:
pubs:673339
Deposit date:
2017-01-28

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