Journal article
High resolution HLA haplotyping by imputation for a British population bioresource.
- Abstract:
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This study aimed to establish the occurrence and frequency of HLA alleles and haplotypes for a healthy British Caucasian population bioresource from Oxfordshire. We present the results of imputation from HLA SNP genotyping data using SNP2HLA for 5553 individuals from Oxford Biobank, defining one- and two-field alleles together with amino acid polymorphisms. We show that this achieves a high level of accuracy with validation using sequence-specific primer amplification PCR. We define six- and ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.9MB)
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- Publisher copy:
- 10.1016/j.humimm.2017.01.006
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Authors
Funding
National Institute for Health Research
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Human Immunology Journal website
- Volume:
- 78
- Issue:
- 3
- Pages:
- 242–251
- Publication date:
- 2017-01-19
- Acceptance date:
- 2017-01-17
- DOI:
- EISSN:
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1879-1166
- ISSN:
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0198-8859
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:673339
- UUID:
-
uuid:420b9152-33a0-4e3e-8f2d-46120d4daf1f
- Local pid:
- pubs:673339
- Deposit date:
- 2017-01-28
Terms of use
- Copyright holder:
- Neville et al
- Copyright date:
- 2017
- Notes:
- © 2017 The Authors. Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics. This is an open access article under the CC BY license, open access funded by the Wellcome Trust.
- Licence:
- CC Attribution (CC BY)
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