Hyaluronan derived from the limbus is a key Regulator of Corneal Lymphangiogenesis
Corneal lymphangiogenesis and angiogenesis leads to the loss of corneal transparency. We have recently shown that in the cornea hyaluronan (HA) is present primarily in the limbal region and plays a key role regulating the limbal stem cell phenotype. Given the HA receptor LYVE-1 is highly expressed in corneal lymphatic vessels we investigated whether HA could play a role in regulating corneal lymphangiogenesis.
Wild-type (wt) and hyaluronan synthase (HAS) kno...
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