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A genome-wide association study of Dupuytren's disease reveals 17 additional variants implicated in fibrosis

Abstract:

Individuals with Dupuytren’s disease (DD) are commonly seen by physicians and surgeons across multiple specialties. It is an increasingly common and disabling fibroproliferative disorder of the palmar fascia, which leads to flexion contractures of the digits, and is associated with other tissue specific fibroses. DD affects between 5 and 25% of people of European descent, and is the most common inherited disease of connective tissue. We undertook the largest GWAS to date in individuals with a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ajhg.2017.08.006

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Funding agency for:
Southam, L
Grant:
098051
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Funding agency for:
Furniss, D
Grant:
097152/Z/11/Z
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Grant:
Oxford Biomedical Research Centre
Publisher:
Cell Press Publisher's website
Journal:
American Journal of Human Genetics Journal website
Volume:
101
Issue:
3
Pages:
417–427
Publication date:
2017-09-07
Acceptance date:
2017-08-03
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
Keywords:
Pubs id:
pubs:712481
UUID:
uuid:4225ba99-9d15-4007-a2d1-bf5a88e5840c
Local pid:
pubs:712481
Deposit date:
2017-08-09

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