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A new role for RGS-1 in vascular function and blood pressure regulation

Abstract:

The Regulator of G-Protein Signalling-1 (RGS1) controls G protein coupled receptor signalling by acting as a GTPase-activating protein for heterotrimeric G proteins. RGS1 has contrasting roles in haematopoietic and non-haematopoietic cells. We have previously shown that Rgs1 regulates macrophage accumulation in Angiotensin II (Ang II)-induced aortic aneurysms and Rgs1-/-ApoE-/- mice are protected from Ang II-induced aortic aneurysm rupture compared to ApoE-/- mice. Conversely, Ang II treatmen...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/cvr/cvy060.254

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
Oxford college:
Exeter College
Role:
Author
ORCID:
0000-0002-1043-4342
Publisher:
Oxford University Press Publisher's website
Journal:
Frontiers in CardioVascular Biology 2018 Journal website
Host title:
Frontiers in CardioVascular Biology 2018
Publication date:
2018-04-23
DOI:
Source identifiers:
846772
Pubs id:
pubs:846772
UUID:
uuid:42304be4-898c-4036-8793-d3215022f81c
Local pid:
pubs:846772
Deposit date:
2018-07-24

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