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Sex differences in the nitrate-nitrite-NO• pathway: Role of oral nitrate-reducing bacteria

Abstract:

Oral reduction of nitrate to nitrite is dependent on the oral microbiome and is the first step of an alternative mammalian pathway to produce nitric oxide in humans. Preliminary evidence suggests important sex differences in this pathway. We prospectively investigated sex-differences following inorganic nitrate supplementation on nitrate/nitrite levels and vascular function, and separately examined sex differences in oral nitrate reduction, and oral microbiota by 16S rRNA profiling. At baseli...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher:
Elsevier Publisher's website
Journal:
Free Radical Biology and Medicine Journal website
Volume:
126
Pages:
113-121
Publication date:
2018-07-20
Acceptance date:
2018-07-18
DOI:
EISSN:
1873-4596
ISSN:
0891-5849
Pmid:
30031863
Language:
English
Keywords:
Pubs id:
910005
Local pid:
pubs:910005
Deposit date:
2020-02-05

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