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Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7

Abstract:

To further resolve the genetic architecture of the inflammatory bowel diseases ulcerative colitis and Crohn's disease, we sequenced the whole genomes of 4,280 patients at low coverage and compared them to 3,652 previously sequenced population controls across 73.5 million variants. We then imputed from these sequences into new and existing genome-wide association study cohorts and tested for association at ∼12 million variants in a total of 16,432 cases and 18,843 controls. We discovered a 0.6...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ng.3761

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Grant:
098051
098051
093885/Z/10/Z
Publisher:
Springer Nature Publisher's website
Journal:
Nature Genetics Journal website
Volume:
49
Issue:
2
Pages:
186-192
Publication date:
2017-01-09
Acceptance date:
2016-12-07
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Source identifiers:
671468
Language:
English
Keywords:
Pubs id:
pubs:671468
UUID:
uuid:42434870-9679-4006-8c2d-762b36eec19c
Local pid:
pubs:671468
Deposit date:
2017-02-21

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