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Ca2+-calmodulin increases RyR2 open probability yet reduces ryanoid association with RyR2

Abstract:

We have shown that physiological levels of Ca(2+)-calmodulin (Ca(2+)CaM; 50-100 nM) activate cardiac ryanodine receptors (RyR2) incorporated into bilayers and increase the frequency of Ca(2+) sparks and waves in cardiac cells. In contrast, it is well known that Ca(2+)CaM inhibits [(3)H]ryanodine binding to cardiac sarcoplasmic reticulum. Since the [(3)H]ryanodine binding technique does not reflect the effects of Ca(2+)CaM on RyR2 open probability (Po), we have investigated, using the reversib...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bpj.2009.07.027

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Medical Research Council More from this funder
British Heart Foundation More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Biophysical Journal Journal website
Volume:
97
Issue:
7
Pages:
1907-1916
Publication date:
2009-10-01
Acceptance date:
2009-07-20
DOI:
ISSN:
0006-3495 and 1542-0086
Pmid:
19804721
Language:
English
Keywords:
Pubs id:
pubs:418392
UUID:
uuid:42435fec-f1df-4d0b-826d-36d7538a82ab
Local pid:
pubs:418392
Deposit date:
2016-09-20

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