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Differential expression of selected histone modifier genes in human solid cancers.

Abstract:

BACKGROUND: Post-translational modification of histones resulting in chromatin remodelling plays a key role in the regulation of gene expression. Here we report characteristic patterns of expression of 12 members of 3 classes of chromatin modifier genes in 6 different cancer types: histone acetyltransferases (HATs)- EP300, CREBBP, and PCAF; histone deacetylases (HDACs)- HDAC1, HDAC2, HDAC4, HDAC5, HDAC7A, and SIRT1; and histone methyltransferases (HMTs)- SUV39H1and SUV39H2. Expression of eac...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/1471-2164-7-90

Authors


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Cancer Research UK More from this funder
European Union More from this funder
National Translational Cancer Research Network More from this funder
Chroma Therapeutics Ltd. More from this funder
Cambridge–MIT Institute More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
BMC genomics Journal website
Volume:
7
Pages:
Article no. 90
Publication date:
2006-01-01
DOI:
EISSN:
1471-2164
ISSN:
1471-2164
Source identifiers:
314831

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