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Journal article

Somatic mutant clones colonize the human esophagus with age

Abstract:

The extent to which cells in normal tissues accumulate mutations throughout life is poorly understood. Some mutant cells expand into clones that can be detected by genome sequencing. We mapped mutant clones in normal esophageal epithelium from nine donors (age range, 20 to 75 years). Somatic mutations accumulated with age and were caused mainly by intrinsic mutational processes. We found strong positive selection of clones carrying mutations in 14 cancer genes, with tens to hundreds of clones...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/science.aau3879

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Role:
Author
ORCID:
0000-0003-1122-4416
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Role:
Author
ORCID:
0000-0001-7546-369X
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Role:
Author
ORCID:
0000-0001-7231-2343
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Role:
Author
ORCID:
0000-0003-3592-1005
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Role:
Author
ORCID:
0000-0002-6201-1587
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Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Journal website
Volume:
362
Issue:
6417
Pages:
911-917
Publication date:
2018-11-23
Acceptance date:
2018-10-03
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
Pmid:
30337457
Source identifiers:
936634
Language:
English
Keywords:
Pubs id:
pubs:936634
UUID:
uuid:42717ba8-cc10-43af-b4f3-e3037d63b381
Local pid:
pubs:936634
Deposit date:
2019-03-15

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