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Journal article

Responder analysis for pain relief and numbers needed to treat in a meta-analysis of etoricoxib osteoarthritis trials: bridging a gap between clinical trials and clinical practice

Abstract:

Background: Population mean changes from clinical trials are difficult to apply to individuals in clinical practice. Responder analysis may be better, but need validating for levels of response and treatment duration. Methods: The numbers of patients with pain relief over baseline (≥15%, ≥30%, ≥50%, ≥70%) at 2, 4, 8 and 12 weeks of treatment were obtained using the WOMAC 100 mm visual analogue pain subscale score for each treatment group in seven randomised placebo-controlled trials of etoric...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/ard.2009.107805

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Research group:
Pain Research
Role:
Author
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Institution:
Musgrove Park Hospital, Belfast
Department:
Department of Rheumatology
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Research group:
Pain Research
Role:
Author
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Institution:
Merck Research Laboratories, Rahway, New Jersey, USA
Role:
Author
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Institution:
Merck Research Laboratories, Rahway, New Jersey, USA
Role:
Author
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Oxford Pain Relief Trust More from this funder
Publisher:
BMJ Publishing Group Publisher's website
Journal:
Annals of the Rheumatic Diseases Journal website
Volume:
69
Issue:
2
Pages:
374-379
Publication date:
2010-02-01
DOI:
EISSN:
1468-2060
Language:
English
Keywords:
Subjects:
UUID:
uuid:42d55016-8edf-4fee-b1ea-708c42a27a97
Local pid:
ora:3640
Deposit date:
2010-04-20

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