Journal article
FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility
- Abstract:
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Compartmentalized cAMP/PKA signalling is now recognized as important for physiology and pathophysiology, yet a detailed understanding of the properties, regulation and function of local cAMP/PKA signals is lacking. Here we present a fluorescence resonance energy transfer (FRET)-based sensor, CUTie, which detects compartmentalized cAMP with unprecedented accuracy. CUTie, targeted to specific multiprotein complexes at discrete plasmalemmal, sarcoplasmic reticular and myofilament sites, reveals ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 3.6MB)
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- Publisher copy:
- 10.1038/ncomms15031
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Authors
Funding
+ BHF Centre of Research Excellence, Oxford
More from this funder
Funding agency for:
Zaccolo, M
Grant:
RE/08/004
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Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 8
- Article number:
- 15031
- Publication date:
- 2017-04-20
- Acceptance date:
- 2017-02-21
- DOI:
- ISSN:
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2041-1723
- Source identifiers:
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690289
Item Description
- Pubs id:
-
pubs:690289
- UUID:
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uuid:42e472d0-cfff-4024-963c-08a93bf7fcf5
- Local pid:
- pubs:690289
- Deposit date:
- 2017-04-20
Terms of use
- Copyright holder:
- Surdo et al
- Copyright date:
- 2017
- Notes:
- This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
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