Delayed cerebral ischaemia after subarachnoid haemorrhage: looking beyond vasospasm.

Journal article

Despite improvements in the clinical management of aneurysmal subarachnoid haemorrhage over the last decade, delayed cerebral ischaemia (DCI) remains the single most important cause of morbidity and mortality in those patients who survive the initial bleed. The pathological mechanisms underlying DCI are still unclear and the calcium channel blocker nimodipine remains the only therapeutic intervention proven to improve functional outcomes after SAH. The recent failure of the drug clazosentan t...

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Authors: Rowland, M; Hadjipavlou, G; Kelly, M; Westbrook, J; Pattinson, K

• Publication status: Published
• Journal: British journal of anaesthesia
• Volume: 109
• Issue: 3
• Pages: 315-329
• Publication date: 2012-09-01
• DOI: 10.1093/bja/aes264
• EISSN: 1471-6771
• ISSN: 0007-0912
• Language: English
• Keywords: Oxidative Stress; Humans; Collateral Circulation; Brain Ischemia; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Vasoconstriction; Subarachnoid Hemorrhage; Apolipoproteins E; Homeostasis; Anticoagulants; Vasospasm, Intracranial