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Neuropeptide-Y causes coronary microvascular constriction and is associated with reduced ejection fraction following ST-elevation myocardial infarction

Abstract:

Aims The co-transmitter neuropeptide-Y (NPY) is released during high sympathetic drive, including ST-elevation myocardial infarction (STEMI), and can be a potent vasoconstrictor. We hypothesized that myocardial NPY levels correlate with reperfusion and subsequent recovery following primary percutaneous coronary intervention (PPCI), and sought to determine if and how NPY constricts the coronary microvasculature.

Methods and results Peripheral venous ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/eurheartj/ehz115

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Oxford college:
Keble College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
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Publisher:
Oxford University Press Publisher's website
Journal:
European Heart Journal Journal website
Volume:
40
Issue:
24
Pages:
1920–1929
Publication date:
2019-03-11
Acceptance date:
2019-02-18
DOI:
EISSN:
1522-9645
ISSN:
0195-668X
Pmid:
30859228
Language:
English
Keywords:
Pubs id:
pubs:982666
UUID:
uuid:4323d747-7513-4522-b87e-e9ccc6757ffa
Local pid:
pubs:982666
Deposit date:
2019-03-28

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