Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis.

Journal article

The structure of the human major histocompatability (MHC) class I molecule HLA-A*0301 (HLA-A3) in complex with a nonameric peptide (KLIETYFSK) has been determined by X-ray crystallography to 2.7 Å resolution. HLA-A3 is a predisposing allele for multiple sclerosis (MS), an autoimmune disease of the central nervous system. The KLIETYFSK peptide is a naturally processed epitope of proteolipid protein, a myelin protein and candidate target for immune-mediated myelin destruction in MS. Comparison ...

Expand abstract

Authors: McMahon, R; Friis, L; Siebold, C; Friese, M; Fugger, L

• Publication status: Published
• Journal: Acta crystallographica. Section D, Biological crystallography
• Volume: 67
• Issue: Pt 5
• Pages: 447-454
• Publication date: 2011-05-01
• DOI: 10.1107/s0907444911007888
• EISSN: 1399-0047
• ISSN: 0907-4449
• Language: English
• Keywords: Amino Acid Sequence; Models, Molecular; HLA-A3 Antigen; Proteolipids; Multiple Sclerosis; Crystallography, X-Ray; Binding Sites; Peptides; Humans; HLA-A2 Antigen