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Heterologous amyloid seeding: revisiting the role of acetylcholinesterase in Alzheimer's disease

Abstract:

Neurodegenerative diseases associated with abnormal protein folding and ordered aggregation require an initial trigger which may be infectious, inherited, post-inflammatory or ideopathic. Proteolytic cleavage to generate vulnerable precursors, such as amyloid-β peptide (Aβ) production via β and γ secretases in Alzheimer's Disease (AD), is one such trigger, but the proteolytic removal of these fragments is also aetiologically important. The levels of Aβ in the central nervous system are regula...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0000652

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Research group:
Central Proteomics Facility
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Synaptica Ltd. More from this funder
More from this funder
Funding agency for:
Thomas, B
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
2
Issue:
7
Article number:
e652
Publication date:
2007-07-01
DOI:
EISSN:
1932-6203
Language:
English
Keywords:
Subjects:
UUID:
uuid:433e113b-dded-4d08-ab4a-59b7a255fb52
Local pid:
ora:5892
Deposit date:
2011-11-11

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