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Nutrient Sensing via mTOR in T Cells Maintains a Tolerogenic Microenvironment.

Abstract:

We have proposed that tolerance can be maintained through the induction, by Treg cells, of a tolerogenic microenvironment within tolerated tissues that inhibits effector cell activity but which supports the generation of further Treg cells by "infectious tolerance." Two important components of this tolerogenic microenvironment depend on metabolism and nutrient sensing. The first is due to the up-regulation of multiple enzymes that consume essential amino acids, which are sensed in naïve T cel...

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Publisher copy:
10.3389/fimmu.2014.00409

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Frontiers in immunology
Volume:
5
Pages:
409
Publication date:
2014-01-01
DOI:
EISSN:
1664-3224
Source identifiers:
484586
Language:
English
Keywords:
Pubs id:
pubs:484586
UUID:
uuid:434c290f-c71a-4100-905b-8f6e54660054
Local pid:
pubs:484586
Deposit date:
2014-09-29

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