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Efficient RNA Polyuridatylation by Noncanonical Poly(A) Polymerases

Abstract:

Nuclear poly(A) polymerase (PAP) polyadenylates nascent mRNAs, promoting their nuclear export, stability, and translation, while the related cytoplasmic polymerase GLD-2 activates translation of deadenylated mRNAs. Here we characterize the biochemical activity of fission yeast Schizosaccharomyces pombe Cid1, a putative cytoplasmic PAP implicated in cell cycle checkpoint controls. Surprisingly, Cid1 has robust poly(U) polymerase activity in vitro, especially when isolated in native mu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/MCB.02209-06

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Association for International Cancer Research More from this funder
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Funding agency for:
Rissland, O
Publisher:
American Society for Microbiology Publisher's website
Journal:
Molecular and Cellular Biology Journal website
Volume:
27
Issue:
10
Pages:
3612-3624
Publication date:
2007-05-01
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
Source identifiers:
28602

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