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Cardiac energetics, oxygenation, and perfusion during increased workload in patients with type 2 diabetes mellitus

Abstract:

Patients with type 2 diabetes mellitus (T2DM) are known to have impaired resting myocardial energetics and impaired myocardial perfusion reserve, even in the absence of obstructive epicardial coronary artery disease (CAD). Whether or not the pre-existing energetic deficit is exacerbated by exercise, and whether the impaired myocardial perfusion causes deoxygenation and further energetic derangement during exercise stress, is uncertain.Thirty-one T2DM patients, on oral antidiabetic therapies w...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/eurheartj/ehv442

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Publisher:
Oxford University Press Publisher's website
Journal:
European Heart Journal Journal website
Volume:
37
Issue:
46
Pages:
3461–3469
Publication date:
2015-09-20
Acceptance date:
2015-08-12
DOI:
EISSN:
1522-9645
ISSN:
0195-668X
Source identifiers:
587078
Language:
English
Keywords:
Pubs id:
pubs:587078
UUID:
uuid:4353a37d-8efc-40b9-aaa3-3d49e6d47f3b
Local pid:
pubs:587078
Deposit date:
2016-07-05

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