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Stakeholder views on secondary findings in whole-genome and whole-exome sequencing: a systematic review of quantitative and qualitative studies

Abstract:

Purpose: As whole-exome and whole-genome sequencing (WES/WGS) move into routine clinical practice, it is timely to review data that might inform the debate around secondary findings (SF) and the development of policies that maximize participant benefit.

Methods: We systematically searched for qualitative and quantitative studies that explored stakeholder views on SF in WES/WGS. Framework analysis was undertaken to identify major themes.

Results: 44 articles report...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/gim.2016.109

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Population Health
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Funding agency for:
Mackley, M
More from this funder
Funding agency for:
Parker, M
Grant:
096527
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Genetics in Medicine Journal website
Publication date:
2016-09-01
Acceptance date:
2016-06-20
DOI:
EISSN:
1530-0366
ISSN:
1098-3600
Source identifiers:
641147
Keywords:
Pubs id:
pubs:641147
UUID:
uuid:435bc69e-6edf-471c-80b7-0594e54df75a
Local pid:
pubs:641147
Deposit date:
2016-09-01

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