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Thesis

Biochemical characterization of a novel deubiquitinating enzyme otubain 1 and investigation into its role in Yersinia infection

Abstract:

Deubiquitinating enzymes (DUBs) constitute a diverse protein family. The specificities and functions of the majority of DUBs are unknown, although their impact on many biological and pathological processes is widely appreciated. This dissertation entails a detailed characterization of otubain 1 (OTUB1), an ovarian tumor domain-containing DUB. The presented work describes OTUB1’s specificity, localization, protein interactions, importance in infection with Yersinia, and proposes a novel mod...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Oxford college:
Jesus College
Role:
Author
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Division:
MSD
Department:
NDM
Role:
Author

Contributors

Division:
MSD
Department:
NDM
Role:
Supervisor
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Funding agency for:
Edelmann, M
Grant:
75743
Publication date:
2010
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:43897bb0-9b24-4876-b67f-bc9ba70d28af
Local pid:
ora:5306
Deposit date:
2011-05-09

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