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The midlife cognitive profiles of adults at high risk of late-onset Alzheimer's disease: The PREVENT study

Abstract:

INTRODUCTION: Although biomarker studies of late-onset Alzheimer's disease suggest pathology to be present decades before diagnosis, little is known about cognitive performance at this stage.

METHODS: A sample of 210 adults (aged 40-59) of whom 103 have a parent diagnosed with dementia (family history subgroup) underwent computerized cognitive testing. Apolipoprotein E (apoE) status was determined, and 193 subjects had magnetic resonance imaging. Distance from dementia onset was est...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jalz.2017.02.008

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
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Alzheimer's Society More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Alzheimers and Dementia Journal website
Volume:
13
Issue:
10
Pages:
1089-1097
Publication date:
2017-03-30
DOI:
EISSN:
1552-5279
ISSN:
1552-5260
Source identifiers:
687889
Language:
English
Keywords:
Pubs id:
pubs:687889
UUID:
uuid:439340ee-27ab-49de-99cf-c805aa8a067d
Local pid:
pubs:687889
Deposit date:
2017-07-18

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