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Journal article

Pathogenic potential of antibodies to the GABA B receptor

Abstract:

GABAB receptor (GABABR) autoantibodies have been detected in the serum of immunotherapy-responsive patients with autoimmune encephalitis. This study aimed to investigate the effect of immunoglobulin G (IgG) from a patient with GABABR antibodies on primary neuronal cultures and acute slices of entorhinal cortex. Primary hippocampal neuronal cultures were incubated with serum immunoglobulin from patients with GABABR or AMPA receptor (AMPAR) antibodies for up to 72 h to investigate their effect ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/epi4.12067

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Oxford college:
St Hugh's College
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
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National Institute for Health Research More from this funder
More from this funder
Grant:
National Specialised Commissioning Group for Neuromyelitis Optica
Epilepsy Research UK More from this funder
More from this funder
Grant:
Intermediate Fellowship
US-UK Fulbright Commission More from this funder
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Publisher:
Wiley Publisher's website
Journal:
Epilepsia Open Journal website
Volume:
2
Issue:
3
Pages:
355-359
Publication date:
2017-07-19
Acceptance date:
2017-06-16
DOI:
ISSN:
2470-9239
Source identifiers:
729225
Keywords:
Pubs id:
pubs:729225
UUID:
uuid:43a6e1a7-fb60-4db3-a315-07f91d77a1e0
Local pid:
pubs:729225
Deposit date:
2018-02-09

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