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Auger electron radionuclide therapy utilising F3 peptide to target the nucleolus

Abstract:

F3 is a 31 amino acid peptide that possesses tumour homing capability and binds to nucleolin (NCL) expressed on the cell surface of malignant cells. Exposure of osteosarcoma (U2OS) cells to F3 peptide was found to shift the distribution of NCL and nucleophosmin (NPM) from the nucleolus to the nucleoplasm, and increase the level of Ki-67 in the nucleoplasm. 111In-labelled F3 (111In-DTPA-F3) was successfully radiosynthesised and was found to be significantly radiotoxic ...

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Institution:
University of Oxford
Oxford college:
Jesus College
Role:
Author

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Supervisor
Role:
Supervisor
Medical Research Council More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
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UUID:
uuid:43bb1e8a-6f52-4eac-b742-0a988562e7fc
Deposit date:
2016-02-22

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