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Two-dimensional TIRF-SIM-traction force microscopy (2D TIRF-SIM-TFM)

Abstract:

Quantifying small, rapidly evolving forces generated by cells is a major challenge for the understanding of biomechanics and mechanobiology in health and disease. Traction force microscopy remains one of the most broadly applied force probing technologies but typically restricts itself to slow events over seconds and micron-scale displacements. Here, we improve >2-fold spatially and >10-fold temporally the resolution of planar cellular force probing compared to its related conventional modali...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-021-22377-9

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Role:
Author
ORCID:
0000-0002-0411-7447
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Role:
Author
ORCID:
0000-0001-9331-265X
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Role:
Author
ORCID:
0000-0001-6059-2472
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
12
Article number:
2169
Publication date:
2021-04-12
Acceptance date:
2021-03-12
DOI:
EISSN:
2041-1723
Pmid:
33846317
Language:
English
Keywords:
Pubs id:
1171515
Local pid:
pubs:1171515
Deposit date:
2021-11-28

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