Thesis icon

Thesis

Total synthesis of (–)-nakadomarin A and an approach to the diazatricyclic core of the madangamines

Abstract:

This dissertation describes work towards two marine alkaloid natural products of the manzamine family. The total synthesis of (–)-nakadomarin A, via two conceptually different strategies is described along with the development of a novel nitro-Mannich-Mannich cascade reaction, which has been applied in a synthesis of the diazatricyclic core of the madangamines.

A short and highly stereoselective synthesis of (–)-nakadomarin A has been developed. A sequential alkyne ring-closing meta...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Research group:
Professor Darren J. Dixon
Oxford college:
Wadham College
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Subjects:
UUID:
uuid:43e8044f-6860-47a2-9850-5f42990d4a68
Local pid:
ora:6880
Deposit date:
2013-06-10

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP