Journal article
Lateral fenestrations in K(+)-Channels explored using molecular dynamics simulations
- Abstract:
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Potassium channels are of paramount physiological and pathological importance and therefore constitute significant drug targets. One of the keys to rationalize the way drugs modulate ion channels is to understand the ability of such small molecules to access their respective binding sites, from which they can exert an activating or inhibitory effect. Many computational studies have probed the energetics of ion permeation, and the mechanisms of voltage gating, but little is known about the rol...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
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(Accepted manuscript, pdf, 2.1MB)
-
- Publisher copy:
- 10.1021/acs.molpharmaceut.5b00942
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Authors
Funding
Engineering and Physical Sciences Research Council
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Biotechnology and Biological Sciences Research Council
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Pfizer
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Bibliographic Details
- Publisher:
- American Chemical Society Publisher's website
- Journal:
- Molecular pharmaceutics Journal website
- Volume:
- 13
- Issue:
- 7
- Pages:
- 2263-2273
- Publication date:
- 2016-07-01
- Acceptance date:
- 2016-05-12
- DOI:
- EISSN:
-
1543-8392
- ISSN:
-
1543-8384
- Pmid:
-
27173896
- Source identifiers:
-
625290
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:625290
- UUID:
-
uuid:43f4299c-97d7-4cb6-a462-3b867220ffd8
- Local pid:
- pubs:625290
- Deposit date:
- 2016-09-19
Terms of use
- Copyright holder:
- © 2016 American Chemical Society
- Copyright date:
- 2016
- Notes:
- This is the author accepted manuscript following peer review version of the article. The final version is available online from American Chemical Society at: 10.1021/acs.molpharmaceut.5b00942
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