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Journal article

Lateral fenestrations in K(+)-Channels explored using molecular dynamics simulations

Abstract:

Potassium channels are of paramount physiological and pathological importance and therefore constitute significant drug targets. One of the keys to rationalize the way drugs modulate ion channels is to understand the ability of such small molecules to access their respective binding sites, from which they can exert an activating or inhibitory effect. Many computational studies have probed the energetics of ion permeation, and the mechanisms of voltage gating, but little is known about the rol...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.molpharmaceut.5b00942

Authors


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Engineering and Physical Sciences Research Council More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
Publisher:
American Chemical Society Publisher's website
Journal:
Molecular pharmaceutics Journal website
Volume:
13
Issue:
7
Pages:
2263-2273
Publication date:
2016-07-01
Acceptance date:
2016-05-12
DOI:
EISSN:
1543-8392
ISSN:
1543-8384
Pmid:
27173896
Source identifiers:
625290
Language:
English
Keywords:
Pubs id:
pubs:625290
UUID:
uuid:43f4299c-97d7-4cb6-a462-3b867220ffd8
Local pid:
pubs:625290
Deposit date:
2016-09-19

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