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Journal article

Rapid effector function in CD8+ memory T cells.

Abstract:

The nature of the CD8+ T cells that underlie antiviral protective immunological memory in vivo is unclear. We have characterized peptide-specific CD8+ T lymphocytes directly ex vivo from peripheral blood in humans with past exposure to influenza virus, using single cell interferon gamma (IFN-gamma) release as a measure of effector function. In individuals in the memory state with respect to influenza virus infection, unrestimulated antigen-specific CD8+ T cells displayed IFN-gamma release wit...

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Publication status:
Published

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Publisher copy:
10.1084/jem.186.6.859

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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Journal:
Journal of experimental medicine
Volume:
186
Issue:
6
Pages:
859-865
Publication date:
1997-09-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Source identifiers:
36093

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