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Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family.

Abstract:

The synucleins (α, β, and γ) are highly homologous proteins thought to play a role in regulating neurotransmission and are found abundantly in presynaptic terminals. To overcome functional overlap between synuclein proteins and to understand their role in presynaptic signaling from mesostriatal dopaminergic neurons, we produced mice lacking all three members of the synuclein family. The effect on the mesostriatal system was assessed in adult (4- to 14-month-old) animals using a combination of...

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Publication status:
Published

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Journal:
Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
31
Issue:
20
Pages:
7264-7274
Publication date:
2011-05-01
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
Source identifiers:
141469
Language:
English
Keywords:
Pubs id:
pubs:141469
UUID:
uuid:440a1b49-5601-4903-8d94-45cb0dc78b69
Local pid:
pubs:141469
Deposit date:
2012-12-19

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