Journal article
Differential effects of PCSK9 variants on risk of coronary disease and ischaemic stroke
- Abstract:
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Aims: PCSK9 genetic variants that have large effects on low density lipoprotein cholesterol (LDL-C) and coronary heart disease (CHD) have prompted the development of therapeutic PCSK9-inhibition. However, there is limited evidence that PCSK9 variants are associated with ischaemic stroke (IS). Methods and Results: Associations of the loss-of-function PCSK9 genetic variant (rs11591147; R46L), and 5 additional PCSK9 variants, with IS and IS subtypes (cardioembol... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 329.0KB)
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- Publisher copy:
- 10.1093/eurheartj/ehx373
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Authors
Funding
+ British Heart Foundation
More from this funder
Funding agency for:
Hopewell, J
Grant:
Intermediate Basic Science
Research Fellowship (FS/14/55/30806
Expand funders...
Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- European Heart Journal Journal website
- Volume:
- 39
- Issue:
- 5
- Pages:
- 354–359
- Publication date:
- 2017-07-17
- Acceptance date:
- 2017-06-16
- DOI:
- EISSN:
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1522-9645
- ISSN:
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0195-668X
Item Description
- Keywords:
- Pubs id:
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pubs:710882
- UUID:
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uuid:441ba70e-e3af-4e22-af4f-2ecd0add4ee3
- Local pid:
- pubs:710882
- Deposit date:
- 2017-08-07
Terms of use
- Copyright holder:
- Hopewell et al
- Copyright date:
- 2017
- Notes:
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Copyright © 2017 The Authors. Published by Oxford University Press on behalf of the European Society of Cardiology.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/),
which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
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