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Journal article

Differential effects of PCSK9 variants on risk of coronary disease and ischaemic stroke

Abstract:
Aims: PCSK9 genetic variants that have large effects on low density lipoprotein cholesterol (LDL-C) and coronary heart disease (CHD) have prompted the development of therapeutic PCSK9-inhibition. However, there is limited evidence that PCSK9 variants are associated with ischaemic stroke (IS). Methods and Results: Associations of the loss-of-function PCSK9 genetic variant (rs11591147; R46L), and 5 additional PCSK9 variants, with IS and IS subtypes (cardioembol... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/eurheartj/ehx373

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
Expand authors...
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Funding agency for:
Hopewell, J
Grant:
Intermediate Basic Science Research Fellowship (FS/14/55/30806
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Funding agency for:
Collins, R
More from this funder
Funding agency for:
Collins, R
More from this funder
Funding agency for:
Collins, R
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Publisher:
Oxford University Press Publisher's website
Journal:
European Heart Journal Journal website
Volume:
39
Issue:
5
Pages:
354–359
Publication date:
2017-07-17
Acceptance date:
2017-06-16
DOI:
EISSN:
1522-9645
ISSN:
0195-668X
Keywords:
Pubs id:
pubs:710882
UUID:
uuid:441ba70e-e3af-4e22-af4f-2ecd0add4ee3
Local pid:
pubs:710882
Deposit date:
2017-08-07

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