Journal article icon

Journal article

A small molecule inhibitor of PDK1/PLCγ1 interaction blocks breast and melanoma cancer cell invasion

Abstract:

Strong evidence suggests that phospholipase Cγ1 (PLCγ1) is a suitable target to counteract tumourigenesis and metastasis dissemination. We recently identified a novel signalling pathway required for PLCγ1 activation which involves formation of a protein complex with 3-phosphoinositide-dependent protein kinase 1 (PDK1). In an effort to define novel strategies to inhibit PLCγ1-dependent signals we tested here whether a newly identified and highly specific PDK1 inhibitor, 2-O-benzyl-myo-inositol...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/srep26142

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Potter, B
Grant:
Senior Investigator 101010
082837
More from this funder
Funding agency for:
Falasca, M
More from this funder
Funding agency for:
Calleja, V
More from this funder
Funding agency for:
Riley, A
Grant:
082837
Expand funders...
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
6
Article number:
26142
Publication date:
2016-05-20
Acceptance date:
2016-04-21
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Source identifiers:
617147
Pubs id:
pubs:617147
UUID:
uuid:4433869d-6bc2-47bd-b9b0-3c94a57a1a88
Local pid:
pubs:617147
Deposit date:
2016-04-22

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP