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Journal article

Structure-function analysis of neutralizing antibodies to H7N9 influenza from naturally infected humans

Abstract:

Little is known about the specificities and neutralization breadth of the H7-reactive antibody repertoire induced by natural H7N9 infection in humans. We have isolated and characterized 73 H7-reactive monoclonal antibodies from peripheral B cells from four donors infected in 2013 and 2014. Of these, 45 antibodies were H7-specific, and 17 of these neutralized the virus, albeit with few somatic mutations in their variable domain sequences. An additional set of 28 antibodies, isolated from young...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41564-018-0303-7

Authors


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Role:
Author
ORCID:
0000-0001-6891-6945
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
Publisher:
Springer Nature Publisher's website
Journal:
Nature Microbiology Journal website
Volume:
4
Pages:
306–315
Publication date:
2018-11-26
Acceptance date:
2018-10-23
DOI:
EISSN:
2058-5276
Pmid:
30478290
Source identifiers:
946919
Language:
English
Pubs id:
pubs:946919
UUID:
uuid:443e9af6-d44a-41b6-a52c-7be1cc6b65cb
Local pid:
pubs:946919
Deposit date:
2019-01-17

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