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Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia

Abstract:

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is believed to confer protection against Plasmodium falciparum malaria, but the precise nature of the protective effecthas proved difficult to define as G6PD deficiency has multiple allelic variants with different effects in males and females, and it has heterogeneous effects on the clinical outcome of P. falciparum infection. Here we report an analysis of multiple allelic forms of G6PD deficiency in a large multi-centre case-control study o...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/eLife.15085

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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More from this funder
Funding agency for:
Spencer, C
Grant:
097364/Z/11/Z
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Funding agency for:
Kwiatkowski, D
Grant:
G0600718
G0600230
G19/9
More from this funder
Funding agency for:
Kwiatkowski, D
Grant:
G0600718
G0600230
G19/9
More from this funder
Grant:
090770/Z/09/Z
MalariaGEN Project 077383/Z/05/Z
077012/Z/05/Z
090532/Z/09/Z
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Grant:
Bill
MelindaGatesFoundationGr
ChallengesinGlobalHealth566
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Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
6
Article number:
e15085
Publication date:
2017-01-09
Acceptance date:
2016-11-03
DOI:
ISSN:
2050-084X
Source identifiers:
670810
Language:
English
Keywords:
Pubs id:
pubs:670810
UUID:
uuid:444aa04a-3384-4bf7-9c75-8a7e7ff44394
Local pid:
pubs:670810
Deposit date:
2017-01-26

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