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Journal article

Effective T-cell responses select human immunodeficiency virus mutants and slow disease progression.

Abstract:

The possession of some HLA class I molecules is associated with delayed progression to AIDS. The mechanism behind this beneficial effect is unclear. We tested the idea that cytotoxic T-cell responses restricted by advantageous HLA class I molecules impose stronger selection pressures than those restricted by other HLA class I alleles. As a measure of the selection pressure imposed by HLA class I alleles, we determined the extent of HLA class I-associated epitope variation in a cohort of Europ...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.00022-07

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Journal:
Journal of virology
Volume:
81
Issue:
12
Pages:
6742-6751
Publication date:
2007-06-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Source identifiers:
20484
Language:
English
Keywords:
Pubs id:
pubs:20484
UUID:
uuid:44509e62-e91c-4cac-90a0-927bcbcc8780
Local pid:
pubs:20484
Deposit date:
2012-12-19

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