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A novel workflow combining plaque imaging, plaque and plasma proteomics identifies biomarkers of human coronary atherosclerotic plaque disruption

Abstract:

BACKGROUND: Atherosclerotic plaque rupture is the culprit event which underpins most acute vascular syndromes such as acute myocardial infarction. Novel biomarkers of plaque rupture could improve biological understanding and clinical management of patients presenting with possible acute vascular syndromes but such biomarker(s) remain elusive. Investigation of biomarkers in the context of de novo plaque rupture in humans is confounded by the inability to attribute the plaque rupture as the sou...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12014-017-9157-x

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Funding agency for:
Fischer, R
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Funding agency for:
Charles, P
Grant:
105605/Z/14Z
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Funding agency for:
Antoniades, C
Grant:
Senior Fellow
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Publisher:
BioMed Central Publisher's website
Journal:
Clinical Proteomics Journal website
Volume:
14
Issue:
1
Article number:
22
Publication date:
2017-06-19
Acceptance date:
2017-06-09
DOI:
EISSN:
1559-0275
ISSN:
1542-6416
Source identifiers:
701997
Language:
English
Keywords:
Pubs id:
pubs:701997
UUID:
uuid:4456540c-a351-476f-9701-63b684a81e8f
Local pid:
pubs:701997
Deposit date:
2017-07-05

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