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Journal article

Clinical and immunological responses in metastatic melanoma patients vaccinated with a high-dose poly-epitope vaccine.

Abstract:

BACKGROUND: Safety and cellular immunogenicity of rising doses and varying regimens of a poly-epitope vaccine were evaluated in advanced metastatic melanoma. The vaccine comprised plasmid DNA and recombinant modified vaccinia virus Ankara (MVA) both expressing a string (Mel3) of seven HLA.A2/A1 epitopes from five melanoma antigens. METHODS: Forty-one HLA-A2 positive patients with stage III/IV melanoma were enrolled. Patient groups received one or two doses of DNA.Mel3 followed by escalating ...

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Publication status:
Published

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Publisher copy:
10.1007/s00262-009-0811-7

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
Cancer immunology, immunotherapy : CII
Volume:
59
Issue:
6
Pages:
863-873
Publication date:
2010-06-01
DOI:
EISSN:
1432-0851
ISSN:
0340-7004
Source identifiers:
117947

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