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Journal article

Transfection of thyroid autoantigens into EBV-transformed B cell lines. Recognition by Graves' disease thyroid T cells.

Abstract:

Autologous EBV-transformed B cell lines (EBVL) from a patient with Graves' disease (GD) were transfected with the expression vector pREP4 encoding thyroid peroxidase (TPO), the thyroid-stimulating hormone receptor (TSHR), or chloramphenicol acetyl transferase. The relevant proteins were expressed. The capacity of EBVL to present transfected Ag was assessed by using EBVL transfected with TPO (EBVL-TPO) to stimulate TPO-specific T cells cloned from autologous thyroid tissue; stimulation indices...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Journal of Immunology
Volume:
152
Issue:
11
Pages:
5572-5580
Publication date:
1994-06-01
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
481664
Language:
English
Keywords:
Pubs id:
pubs:481664
UUID:
uuid:4484a48e-8da9-4f18-98da-1c78e2f3fa8b
Local pid:
pubs:481664
Deposit date:
2014-08-29

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