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The blood-brain barrier and the inflammatory response.

Abstract:

The environment of the brain is controlled by a sophisticated endothelial barrier that prevents the free entry of solutes from the blood. It is commonly assumed that this blood-brain barrier (BBB) also prevents the entry of leukocytes into the central nervous system. However, recent evidence in animal models shows that this is not the case, and leukocytes can cross an intact BBB during health and disease. Indeed, in many neurological diseases, including Alzheimer's disease, prion diseases and...

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Molecular medicine today
Volume:
3
Issue:
8
Pages:
335-341
Publication date:
1997-08-01
DOI:
ISSN:
1357-4310
Source identifiers:
383093
Language:
English
Keywords:
Pubs id:
pubs:383093
UUID:
uuid:44888538-f698-4bb7-840c-f17b689c5f67
Local pid:
pubs:383093
Deposit date:
2013-11-16

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