Journal article
Recognition of CpG island chromatin by KDM2A requires direct and specific interaction with linker DNA.
- Abstract:
-
Up to 70% of human genes are associated with regions of nonmethylated DNA called CpG islands (S. Saxonov, P. Berg, and D. L. Brutlag, Proc. Natl. Acad. Sci. U. S. A. 103:1412-1417, 2006). Usually associated with the 5' end of genes, CpG islands are thought to impact gene expression. We previously demonstrated that the histone demethylase KDM2A is specifically recruited to CpG islands to define a unique chromatin architecture and highlight gene regulatory regions in large and complex mammalian...
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- Publication status:
- Published
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- Publisher copy:
- 10.1128/mcb.06332-11
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Bibliographic Details
- Journal:
- Molecular and cellular biology
- Volume:
- 32
- Issue:
- 2
- Pages:
- 479-489
- Publication date:
- 2012-01-01
- DOI:
- EISSN:
-
1098-5549
- ISSN:
-
0270-7306
- Source identifiers:
-
205865
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:205865
- UUID:
-
uuid:44a63325-f9db-4dce-bfa3-9f1a2097dc9b
- Local pid:
- pubs:205865
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2012
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