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Recognition of CpG island chromatin by KDM2A requires direct and specific interaction with linker DNA.

Abstract:

Up to 70% of human genes are associated with regions of nonmethylated DNA called CpG islands (S. Saxonov, P. Berg, and D. L. Brutlag, Proc. Natl. Acad. Sci. U. S. A. 103:1412-1417, 2006). Usually associated with the 5' end of genes, CpG islands are thought to impact gene expression. We previously demonstrated that the histone demethylase KDM2A is specifically recruited to CpG islands to define a unique chromatin architecture and highlight gene regulatory regions in large and complex mammalian...

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Publication status:
Published

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Publisher copy:
10.1128/mcb.06332-11

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Journal:
Molecular and cellular biology
Volume:
32
Issue:
2
Pages:
479-489
Publication date:
2012-01-01
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
Source identifiers:
205865
Language:
English
Keywords:
Pubs id:
pubs:205865
UUID:
uuid:44a63325-f9db-4dce-bfa3-9f1a2097dc9b
Local pid:
pubs:205865
Deposit date:
2012-12-19

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