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Journal article

A large polysaccharide produced by helicobacter hepaticus induces an anti-inflammatory gene signature in macrophages

Abstract:

Interactions between the host and its microbiota are of mutual benefit and promote health. Complex molecular pathways underlie this dialog, but the identity of microbe-derived molecules that mediate the mutualistic state remains elusive. Helicobacter hepaticus is a member of the mouse intestinal microbiota that is tolerated by the host. In the absence of an intact IL-10 signaling, H. hepaticus induces an IL-23-driven inflammatory response in the intestine. Here we investigate the interactions...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.chom.2017.11.002

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
Role:
Author
ORCID:
0000-0003-0971-8310
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
Role:
Author
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Spanish Ministry of Education, Culture, and Sport More from this funder
Fondation Louis Jeantet More from this funder
More from this funder
Grant:
Advanced Grant Ares(2013)3687660
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Publisher:
Cell Press Publisher's website
Journal:
Cell Host and Microbe Journal website
Volume:
22
Issue:
6
Pages:
733-745.e5
Publication date:
2017-12-13
Acceptance date:
2017-10-06
DOI:
EISSN:
1934-6069
ISSN:
1931-3128
Pmid:
29241040
Language:
English
Keywords:
Pubs id:
pubs:811335
UUID:
uuid:44b2ba0f-9858-48a1-9bf0-c906bb676e03
Local pid:
pubs:811335
Deposit date:
2018-02-05

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