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Journal article

Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody

Abstract:

The quest to develop an effective malaria vaccine remains a major priority in the fight against global infectious disease. An approach with great potential is a transmission-blocking vaccine which induces antibodies that prevent establishment of a productive infection in mosquitos that feed on infected humans, thereby stopping the transmission cycle. One of the most promising targets for such a vaccine is the gamete surface protein, Pfs48/45. Here we establish a system for production of full-...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-018-06340-9

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
ORCID:
0000-0003-4779-3733
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Issue:
1
Pages:
3822
Publication date:
2018-09-20
Acceptance date:
2018-08-29
DOI:
EISSN:
2041-1723
Pmid:
30237518
Language:
English
Keywords:
Pubs id:
pubs:921051
UUID:
uuid:44bda525-c049-4409-94cc-dda51f9d17f0
Local pid:
pubs:921051
Deposit date:
2018-10-13

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