Thesis
Investigating the mechanisms by which influenza A viruses induce and subsequently dampen the Type I interferon response
- Abstract:
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The activation of antiviral innate immune responses by influenza A viruses plays a keys role in influenza virus infections. The recognition of viral RNA by the pattern recognition receptor RIG-I leads to the induction of the expression of Type I Interferons, which induce an antiviral state, and to the activation of the inflammasome, which leads to inflammation. This thesis focuses on investigating both the mechanisms by which RIG-I is activated by influenza A viruses and the mechanisms...
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Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- UUID:
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uuid:44f1a810-b763-44f8-9ef7-f4c3326d3fdf
- Deposit date:
- 2017-10-23
Terms of use
- Copyright holder:
- Long, J
- Copyright date:
- 2016
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