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Thesis

Investigating the mechanisms by which influenza A viruses induce and subsequently dampen the Type I interferon response

Abstract:

The activation of antiviral innate immune responses by influenza A viruses plays a keys role in influenza virus infections. The recognition of viral RNA by the pattern recognition receptor RIG-I leads to the induction of the expression of Type I Interferons, which induce an antiviral state, and to the activation of the inflammasome, which leads to inflammation. This thesis focuses on investigating both the mechanisms by which RIG-I is activated by influenza A viruses and the mechanisms...

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Division:
MSD
Department:
Pathology Dunn School
Role:
Author

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Role:
Supervisor
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Funding agency for:
Long, J
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:44f1a810-b763-44f8-9ef7-f4c3326d3fdf
Deposit date:
2017-10-23

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